The Impact of Helicobacter Pylori Infection on Lung Function and Severity of Bronchial Hyperresponsiveness in Subjects with Allergic Asthma | Semantic Scholar (2024)

It is indicated that in cross-sectional analysis there is higher prevalence of H. pylori seropositivity in COPD than in non-COPD patients, as well as that H.pylori infection has not significant impact on lung function in COPd patients.

The primary goal of this chapter is to observe association between H. pylori infection in the gastric mucosa and of autoimmune thyroid diseases vitamin B12 deficiency because eradication of H.pylori can prevent the development of complications.

There was no association between H. pylori exposure and either chronic obstructive pulmonary disease (COPD), measures of allergic disease or decline in lung function, and this association was not independent of height or socio-economic status.

Despite the sero-epidemiological association of H. pylori infection with many inflammatory conditions, the data show no significant association between mild asthma and H.pylori infections.

Novel epidemiological data from a cross-sectional survey show that in subjects with active Helicobacter pylori infection the prevalence of asthma, eczema, allergic rhinitis is lower than in H.pylori-negative subjects.

There was a 30% reduction in the prevalence of all three atopic disorders in people who had active H. pylori infection, although for each individual atopic disorder the numbers were not quite large enough to reach statistical significance.

The present review summarizes the current literature, including the own studies, concerning the association between H. pylori infection and respiratory diseases and concludes that larger studies should be undertaken to confirm the observed results and to clarify the underlying pathogenetic mechanisms.

Both systemic and mucosal administrations of HP-NAP are successful in reducing eosinophilia, immunoglobulin E and systemic Th2 cytokines at the bronchial level, and identify H. pylori as a candidate for novel strategies for the prevention and treatment of allergic diseases.

In adjunct to model studies, there is experimental evidence in man that the potential mechanisms of bronchial hyperresponsiveness can be divided into those causing hypersensitivity and those responsible for the increase in the maximal attainable degree of airway narrowing.

H pylori infection was associated with growth delay in older children, poor socioeconomic conditions, and household overcrowding, consistent with the hypothesis that H pyloris infection is one of the environmental factors capable of affecting growth.

Infection with H. pylori is associated with an increased risk of gastric adenocarcinoma and may be a cofactor in the pathogenesis of this malignant condition.

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